RESISTANCE MECHANISMS IN HUMAN LUNG-CANCER

Drug resistance is an important problem in the treatment of lung cance r. Patients become resistant not only to the drugs used initially, but also to those to which they have not yet been exposed. Multiple mecha nisms contribute to drug resistance in this disease, all or any combin ation of which may occur simultaneously within each cell, producing on overall drug resistant phenotype. The limited success of hitherto app lied strategies in their ability to circumvent drug resistance in lung cancer suggests that new approaches are required.