SYNTHESIS OF ALPHA-METHYLENE-BETA-LACTONES BY NICKEL-CATALYZED HYDROCARBOXYLATION OF PROPARGYL ALCOHOLS

Authors
ROSOLEVI G AMER I
Citation
G. Rosolevi et I. Amer, SYNTHESIS OF ALPHA-METHYLENE-BETA-LACTONES BY NICKEL-CATALYZED HYDROCARBOXYLATION OF PROPARGYL ALCOHOLS, Journal of molecular catalysis. A, Chemical, 106(1-2), 1996, pp. 51-56
Citations number
16
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis. A, Chemical → ACNP
ISSN journal
13811169
Volume
106
Issue
1-2
Year of publication
1996
Pages
51 - 56
Database
ISI
SICI code
1381-1169(1996)106:1-2<51:SOABNH>2.0.ZU;2-P
Abstract
Substituted alpha-methylene-beta-lactones (2) were prepared in two ste ps, from substituted propargyl alcohols, by hydrocarboxylation under a tmospheric pressure of CO in the presence of nickel cyanide under phas e-transfer conditions. The alpha-methylene-3-hydroxypropanoic acid der ivatives so formed (12-40% yield), were cyclized with mesyl chloride ( 22-56% yield).