PRADIMICIN-T1 AND PRADIMICIN-T2, NEW ANTIFUNGAL ANTIBIOTICS PRODUCED BY AN ACTINOMYCETE .2. STRUCTURES AND BIOSYNTHESIS

Authors
HASEGAWA T KAKUSHIMA M HATORI M ABURAKI S KAKINUMA S FURUMAI T OKI T
Citation
T. Hasegawa et al., PRADIMICIN-T1 AND PRADIMICIN-T2, NEW ANTIFUNGAL ANTIBIOTICS PRODUCED BY AN ACTINOMYCETE .2. STRUCTURES AND BIOSYNTHESIS, Journal of antibiotics, 46(4), 1993, pp. 598-605
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
4
Year of publication
1993
Pages
598 - 605
Database
ISI
SICI code
0021-8820(1993)46:4<598:PAPNAA>2.0.ZU;2-L
Abstract
Pradimicins Tl and T2 are new members of the pradimicin family of anti biotics produced by an actinomycete strain AA3798. Pradimicins T1 and T2 are dihydrobenzo[a]naphthacenequinones substituted with 3 and 2 sug ar moieties, respectively. The salient feature in their structures is an L-xylose attached to the phenolic hydroxyl group at C-11. Bioconver sion experiments using a blocked mutant B-54 of strain AA3798 not only explored a plausible biosynthetic pathway of pradimicins TI and T2, b ut also provided evidence of 5S,6S configuration.