DETERMINANTS FOR CORONARY HEART-DISEASE IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS - LESSONS FROM THE DIABETES INTERVENTION STUDY

In NIDDM a clustering of established coronary risk factors, e.g. the m etabolic syndrome is responsible for excessive incidence of myocardial infarction. The harmful effects of these risk factors are aggravated by poor glucose control. Hyperinsulinaemia is associated with a higher level of risk factors for coronary heart disease. Individuals with su bsequent myocardial infarction exhibit higher levels of serum insulin at entry. However, insulin in multivariate analysis was no independent risk factor. Perfect control of blood glucose, triglycerides and bloo d pressure was associated with a lower incidence of coronary heart dis ease. By extrapolation an integrated approach to correct the anomalies of the metabolic syndrome seems to be necessary to prevent macroangio pathy and improve life expectancy.