GENOTOXICITY STUDIES OF GRISEOFULVIN IN DROSOPHILA

Genotoxic effects of griseofulvin, a mycotoxin with wide application i n the therapy of dermatophytoses, were studied in the somatic and germ line cells of Drosophila melanogaster. Third and second instar larvae carrying genetic markers mwh and flr(3) on chromosome 3 were used to study the genotoxic effects in the wing primordial cells and the stand ard Base technique was followed to study the genotoxic effects in the germ line cells. On the basis of the results obtained, it is concluded that griseofulvin is genotoxic both in the somatic and germ line cell s of Drosophila following chronic larval feeding.