CERVICAL INTRAEPITHELIAL NEOPLASIA IN WOMEN INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS

Objective: To investigate the relationship between human immunodeficie ncy virus (HIV) and cervical intraepithelial neoplasia (CIN), Design: A prospective study to determine the prevalence of cervical intra-epit helial neoplasia in 111 HIV-positive women. Methods: In total, 111 HIV + women were enrolled and underwent cervical biopsy and CD4 T-lymphocy te determination. Of the 111 women, 26 (23.4%) had CIN and another 26 (23.4%) had histologic evidence of cervicitis. Results: No significant difference was found between transmission group, CDC stage of disease , CD4 T-lymphocyte count and pregnancy. There was a significant associ ation with concomitant human papillomavirus (HPV) infection (P < 0.001 ). Conclusion: Public health measures are needed to provide Papanicola ou smear screening and appropriate clinical follow-up and treatment of women infected with the human immunodeficiency virus.