CENTRAL COMPOSITE DESIGN FOR THE RAPID OPTIMIZATION OF RUGGEDNESS ANDCHIRAL SEPARATION OF AMLODIPINE IN CAPILLARY ELECTROPHORESIS

Systematic optimisation with central composite design offers an effici ent route for rapid optimisation of resolution with multiple interacti ng parameters in chiral CE. This is illustrated by separations of amlo dipine with alpha-CD as chiral selector in the running buffer, for whi ch the predicted performance of central composite design is assessed. The utility of response surface methodology for locating optimum rugge dness in CE is also described. (C) 1995 Wiley-Liss, Inc.