DEGRADATION AND RACEMIZATION OF ZOPICLONE ENANTIOMERS IN PLASMA AND PARTIALLY AQUEOUS-SOLUTIONS

Authors
FERNANDEZ C GIMENEZ F MAYRARGUE J THUILLIER A FARINOTTI R
Citation
C. Fernandez et al., DEGRADATION AND RACEMIZATION OF ZOPICLONE ENANTIOMERS IN PLASMA AND PARTIALLY AQUEOUS-SOLUTIONS, Chirality, 7(4), 1995, pp. 267-271
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
7
Issue
4
Year of publication
1995
Pages
267 - 271
Database
ISI
SICI code
0899-0042(1995)7:4<267:DAROZE>2.0.ZU;2-8
Abstract
We investigated the degradation and racemization of zopiclone (ZOP) en antiomers in plasma and partially aqueous solutions (ethanol:phosphate buffer). Degradation and racemization increased with increasing pH an d temperature. Degradation products were identified by means of mass s pectrometry, which revealed hydrolysis of the carbamate function and o pening of the pyrrolidone ring. In plasma, neither degradation nor rac emization occurred after 6 months of storage at -20 degrees C and subs equent extraction. (C) 1995 Wiley-Liss, Inc.