A SIMPLE SCID MOUSE MODEL FOR HIV RESEARCH

The engraftment in SCID mice of human cells susceptible to HIV-1 infec tion was studied. Repopulation of various tissues by CD4(+) human cell s in transplanted SCID recipients was monitored via FAGS, PCR, and imm unohistology. Injection into SCID mice resulted in extensive prolifera tion of CD4(+) cells in the peritoneal cavity, secondary lymphoid orga ns and other organs. The SCID-CD4(+) mouse may provide a simple model system for in vivo research purposes such as HIV-1 infection, anti-HIV drug screening, and vaccine development.