D. Crowther et al., NITRATE AND NITRITE DETERMINATION IN COMPLEX MATRICES BY GRADIENT IONCHROMATOGRAPHY, Analytical communications, 33(2), 1996, pp. 51-52
Simultaneous determination of nitrate and nitrite in human serum has b
een accomplished using gradient ion chromatography and direct UV detec
tion, with centrifugal ultrafiltration as the only pretreatment. The m
ethod has advantages over previous techniques in both ease of use and
cost per assay. The sensitivity is adequate for use as a monitor of ni
tric oxide induced changes in serum nitrate and nitrite levels.