A pulsed Holmium:YAG-laser (lambda = 2120 nm) was used for the first t
ime clinically in tumour surgery. The primary lesion of a transitional
cell carcinoma of the nasopharynx with metastatic disease in the neck
(T2N2Mo) was laser resected in a photoablative manner with a minor th
ermal component without danger of damage to the skull base. Neck disse
ction was performed by conventional surgery. In comparison to laser ty
pes depending primarily on the thermal effects of laser-tissue interac
tion the coagulative necrosis zone following Holmium:YAG-laser surgery
is small and there is no area of carbonisation. Macroscopic wound hea
ling showed no complications and was completed after three weeks. At t
his time radiation therapy was started. The results of the histologica
l examination and the physical properties of this new infrared laser s
ystem are discussed as well as the possibilities of flexible fiber Hol
mium:YAG endoscopic laser tumour surgery in clinical use.