In this study we investigated the epidemiology of a cluster of cutaneo
us infections owing to Aspergillus niger, which occurred in neutropeni
c patients in a bone marrow transplant unit. Heavy environmental conta
mination with the mould was found in the ward kitchen adjacent to the
unit. The clinical and environmental isolates were typed by random amp
lification of polymorphic DNA (RAPD), which showed one of the patients
was infected with the same strain as that isolated repeatedly from th
e kitchen area. In another case, contaminated stockinette material was
implicated as the source of infection. Thorough cleaning of the ward
kitchen resulted in no further cases on the unit. This highlights the
fact that aspergilli may spread to patients by air, food or other vehi
cles, and underlines the importance of searching for a source and ensu
ring high levels of hospital hygiene are maintained.