MATRIX-ASSISTED LASER-DESORPTION IONIZATION OF LOW-MOLECULAR-WEIGHT COMPOUNDS BY FOURIER-TRANSFORM LASER MICROPROBE MASS-SPECTROMETRY WITH EXTERNAL SOURCE

Authors
KOLLENSPERGER G POELS K VANVAECK L VANROY W STRUYF H GRASSERBAUER M
Citation
G. Kollensperger et al., MATRIX-ASSISTED LASER-DESORPTION IONIZATION OF LOW-MOLECULAR-WEIGHT COMPOUNDS BY FOURIER-TRANSFORM LASER MICROPROBE MASS-SPECTROMETRY WITH EXTERNAL SOURCE, Rapid communications in mass spectrometry, 10(5), 1996, pp. 538-550
Citations number
35
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
10
Issue
5
Year of publication
1996
Pages
538 - 550
Database
ISI
SICI code
0951-4198(1996)10:5<538:MLIOLC>2.0.ZU;2-Z
Abstract
Fourier transform laser microprobe mass spectrometry is used to perfor m matrix-assisted laser desorption/ionization (MALDI) experiments on l ow molecular weight compounds in the range up to 2 kDa. The optimal mo lar ratio of analyte to matrix is determined. The use of fructose as c o-matrix and the effect of laser irradiance on the mass spectra are st udied. The typical power density in MALDI is compared to the laser onl y mode. Specific experiments concerning the cationization of the analy te are described. The observations are interpreted in terms of previou s concepts about DI in laser mass spectrometry of solids.