A PRACTICAL SYNTHESIS OF BOTH ENANTIOMERS OF 1-AMINO-2-PROPANOL AND PROPYLENE-OXIDE

Authors
ROSSEN K SIMPSON PM WELLS KM
Citation
K. Rossen et al., A PRACTICAL SYNTHESIS OF BOTH ENANTIOMERS OF 1-AMINO-2-PROPANOL AND PROPYLENE-OXIDE, Synthetic communications, 23(8), 1993, pp. 1071-1074
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
23
Issue
8
Year of publication
1993
Pages
1071 - 1074
Database
ISI
SICI code
0039-7911(1993)23:8<1071:APSOBE>2.0.ZU;2-0
Abstract
A practical large-scale synthesis of both enantiomers of 1-amino-2-pro panol 1 from L- and D-threonine is described. Greater than 99% e.e. pr opylene oxide 2 is obtained from 1 through a diazotization under basic conditions.