AN EFFICIENT SYNTHESIS OF ISOFRAXIDIN

Authors
ROUESSAC F LECLERC A
Citation
F. Rouessac et A. Leclerc, AN EFFICIENT SYNTHESIS OF ISOFRAXIDIN, Synthetic communications, 23(8), 1993, pp. 1147-1153
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
23
Issue
8
Year of publication
1993
Pages
1147 - 1153
Database
ISI
SICI code
0039-7911(1993)23:8<1147:AESOI>2.0.ZU;2-Y
Abstract
An improved procedure for the preparation of isofraxidin 1 a well know n natural coumarin, through transformation of syringaldehyde is report ed. The cyclization of 7 to the coumarinic carboxylic acid 8 is readil y performed by cold concentrated sulfuric acid. The overall yield to 1 by this convenient route is near 50%.