C. Castelobranco et al., PLASMA-LIPIDS, LIPOPROTEINS AND APOLIPOPROTEINS IN HIRSUTE WOMEN, Acta obstetricia et gynecologica Scandinavica, 75(3), 1996, pp. 261-265
Objective. To determine whether lipid alterations in hirsute women are
due to excessive androgen, low estrogen or to a combination of these
abnormalities. Design. Cross sectional study. Patients. Forty-five hir
sute women between 15 and 39 years of age. Main outcome measures. FSH,
LH, 17 beta-estradiol, PRL, testosterone, androstenedione, DHEAS, 17-
OH-progesterone, sex hormone binding globulin, cholesterol, LDL, HDL,
triglycerides, and apolipoproteins A-I and B. Results. Testosterone wa
s correlated with triglycerides (r: 0.76, p<0.01), HDL (r: -0.61, p<0.
01) and LDL (r: 0.50, p<0.05). Both HDL (r : 0.66, p<0.01) and LDL (r
: -0.57, p<0.01) were correlated with estradiol. Total cholesterol was
also correlated with estradiol (r: -0.52, p<0.05). Cross adjusted cor
relations revealed that, after adjusting for estradiol, lipids were as
sociated with testosterone and that estradiol was also correlated with
lipids when adjusted for testosterone. Conclusion. The results sugges
t that altered lipids in women with hyperandrogenism could result from
independent effects of androgens and estrogens. (C) Acta Obstet Gynec
ol Scand 1996