THE POSSIBILITY OF ACTIVE FORM OF VITAMIN-A AND VITAMIN-D AS SUPPRESSORS ON ADIPOCYTE DEVELOPMENT VIA LIGAND-DEPENDENT TRANSCRIPTIONAL REGULATORS

The study aimed to systematically examine the effects of fat soluble v itamins and their analogs on terminal differentiation of adipocytes on the cellular and molecular aspects, It is well known that fat soluble vitamins especially vitamins A and D inhibit the differentiation of a dipocytes in cultured cells, Furthermore, it has been revealed that th e low level of dietary fat soluble vitamins, especially vitamin A and carotenoid actively stimulate the development of adipose tissue, namel y bovine marbling in vivo. We have shown that the expression of retino ic acid receptor (RAR) alpha and gamma. retinoid X receptor (RXR) alph a and beta, and vitamin D receptor (VDR) mRNA were abundant in rat adi pose tissue and 3T3-L1 cells, The autoregulated amplification and redu ction of RAR, RXR and VDR mRNA by their own ligands, were observed in 3T3-L1 cells, Finally, we proposed the model of vitamins A and D as su ppressors on adipocyte development through retinoid/thyroid/vitamin D/ fatty acid-activated/peroxisomal proliferator-activated receptor's sub family.