RESOLVED 2-ARYLCYCLOHEXYLAMINES - EFFECTS ON RESERPINE AKINESIA AND CENTRAL-NERVOUS-SYSTEM MONOAMINE SYNTHESIS

Authors
ANDERSSON B WIKSTROM H HJORTH S SVENSSON K CARLSSON A SUNDELL S LUNDMARK M LARGENT B
Citation
B. Andersson et al., RESOLVED 2-ARYLCYCLOHEXYLAMINES - EFFECTS ON RESERPINE AKINESIA AND CENTRAL-NERVOUS-SYSTEM MONOAMINE SYNTHESIS, European journal of medicinal chemistry, 28(1), 1993, pp. 63-69
Citations number
12
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
1
Year of publication
1993
Pages
63 - 69
Database
ISI
SICI code
0223-5234(1993)28:1<63:R2-EOR>2.0.ZU;2-E
Abstract
A series of cis- and trans-2-arylcyclohexylamines were synthesized and resolved. The absolute configuration was determined by single-crystal X-ray analysis. Some of the compounds, and especially racemic 2-(3-hy droxyphenyl)-N,N-dipropylcyclohexylamine showed a marked locomotor sti mulation in reserpinized rats. However, these compounds displayed only minor effects on dopamine and 5-hydroxytryptamine synthesis rates, in dicating a non-dopaminergic and/or serotonergic mechanism for this sti mulation.