RESISTANCE OF HEMATOENCEPHALIC BARRIER IN TICK-BORNE NEUROINFECTION (LYME-DISEASE TICK-BORNE ENCEPHALITIS)

The dynamic state of hematoencephalic barrier (HEB) was estimated in R ussian tick-borne encephalitic (RTBE) and in meningeal syndrome (Lyme' s disease, LD). The enzyme immunoassays of neurospecific proteins in b lood serum such as alpha(1)-BG and enolase (NSE) were performed in the course of disease. The break of HEB at blood-brain direction was prov ed in patients with RTBE and LD for the proteins mentioned above. The blood serum NSE levels as well as their dynamics confirmed the functio nal alteration of brain neurons' permeability in LD and pronounced des truction of such neurons in RTBE. The acute increase of blood NSE conc entration was observed within some days before the development of clin ical signs of paresis. The authors suppose that the enzyme immunoassay s of neurospecific proteins which are of rather high value for HEB per meability. and neuronal destruction control may be successfully applie d in monitoring of both therapy's efficacy and individualization of ph armacotherapy.