INFLUENCE OF ALCOHOLIC AFFECTIVE-DISORDER S PHARMACOTHERAPY ON PSYCHOSEMANTICS

90 alcoholic patients (II stage of alcoholism) with secondary affectiv e disorders (anxiety, depression) were divided into 4 groups. The pati ents of the first group received the GABA receptor ligand baclofen dur ing 3 weeks. Sybazon preparation was used in the second group, while t he patients of the third group were treated with amitriptyline. Placeb o was applied in the forth group. The clinical psychological tests dem onstrated that all drugs caused quite effective relief of affective di sorders. Psychosemantic tests application showed that the pharmacother apy caused positive changes in patients of 1 - 3 groups. These changes touched on both system of personal estimations and relations of perso nality to himself and to the world around i.e. psychosemantic sphere. Such changes in psychosemantic sphere were not observed in the 4-th gr oup of patients (placebo). Besides it was revealed that each drug caus ed some specific changes in psychosemantic sphere. The result obtained were supposed to have some theoretical value in comprehension of brai n-psychics relations as well as the applied significance for adequate choice of affective disorders pharmacotherapy of alcoholic patients.