A study of the causative agents of enteritis in domestic rabbits from
44 different accessions is described. In descending order of frequency
, the organisms most commonly demonstrated were intestinal and hepatic
coccidia (Eimeria species), Escherichia coli, Clostridium spp., Salmo
nella, Bacillus piliformis, and rotavirus. The species of Eimeria iden
tified included those moderately pathogenic and coccidia of low pathog
enicity. Using seven antisera against known enterpathogenic strains of
E. coli, only one strain, O15, was identified in three cases. Clostri
dium perfringens or C. spiroforme was demonstrated in the intestinal c
ontents in 11 cases, and lesions compatible with clostridial enteropat
hy were identified on gross and histopathology. In a serological surve
y, over 50% of 200 fryer rabbits submitted to Ontario abattoirs and of
animals from commercial rabbitries had detectable antibody to rotavir
us, indicating the widespread distribution of rotaviral infections in
this species. In the cases of enteritis studied, two or more potential
ly pathogenic organisms were frequently identified, emphasizing that s
everal different organisms may be acting in concert to produce clinica
l disease.