SIGNIFICANCE OF ENTERAL FEEDING FOR THE G ENE-EXPRESSION OF THE GLUCOSE-TRANSPORTER GLUT2

A rat model of isogenic accessory small bowel transplantation was used to investigate the significance of enteral feeding for the gene expre ssion of GLUT2 and SGLT1. When the accessory bowel was excluded for si x weeks from the enteric passage, the expression of GL UT2 but not SGL T1 was significantly reduced. When the accessory small bowel transplan t was converted into an orthotopic position the expression of GLUT2 no rmalized again. Thus enteral feeding plays an important role in the re gulation the gene expression of GLUT2.