ABOUT THE ROLE OF CLASSICAL AND NONCLASSI CAL MAJOR HISTOCOMPATIBILITY ANTIGENS (MHCS) AND THEIR IMPACT ON THE NONADAPTIVE IMMUNE-RESPONSE AFTER HEART-TRANSPLANTATION IN THE RAT MODEL
B. Dresske et al., ABOUT THE ROLE OF CLASSICAL AND NONCLASSI CAL MAJOR HISTOCOMPATIBILITY ANTIGENS (MHCS) AND THEIR IMPACT ON THE NONADAPTIVE IMMUNE-RESPONSE AFTER HEART-TRANSPLANTATION IN THE RAT MODEL, Langenbecks Archiv fur Chirurgie, 1996, pp. 123-128
The impact of non-adaptive effector cells (NK-cells and macrophages) f
ollowing allogeneic transplantation of solid organs is still subject o
f controversies. The here presented study outlines the importance of t
hese cell subpopulations in terms such as kinetic recruitment into the
transplant and extent of histopathomorphologic tissue injury within t
he organ. Both are significantly enhanced in the allogeneic as compare
d to the syngeneic setting. Protein products coded for by the RT1.C-re
gion of the rat have been shown to function as NK-cell activation mole
cules and appear to exert an influence on the rejection process, since
, in certain strain combinations, they can lead to chronic rejection w
ithin 3 weeks following transplantion.