RESTORATION OF XENOBIOTIC LIVER-METABOLIS M BY INHIBITION OF NO-SYNTHESIS IN AN ANIMAL-MODEL OF INFLAMMATORY LIVER DYSFUNCTION

In septic patients, inflammatory dysfunction of the liver represents a n important therapeutic problem. In this report we demonstrate signifi cant recovery of xenobiotic liver metabolism in an in vivo rat model w ith inflammatory liver dysfunction, using N-Monomethyl-L-Arginine as a nitrite-synthesis-inhibitor. As tests of hepatic function we used the aminopyrine breath test and the metabolism of vecuronium, a clinicall y relevant muscle relaxant.