A METABOLIC SYNDROME IN DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS, A CONTROLLED-STUDY

Objective. In addition to diabetes mellitus (DM), high incidence of co mmon metabolic conditions such as dyslipidemia (DL) and hyperuricemia (HU) has been found in patients with diffuse idiopathic skeletal hyper ostosis (DISH). Our objective was to confirm such observations compari ng data from patients with DISH and appropriate controls. Methods, One hundred randomly identified inpatients with DISH were compared with 1 00 DISH-free inpatients with various rheumatic disorders matched for a ge, sex, body mass index, and excess body weight, The prevalence of me tabolic disturbances was compared in the 2 groups, Data was analyzed s tatistically by chi-squared test and 4-fold table analysis. Results, I n our DISH population, metabolic abnormalities were found in 70%, vers us 45% in the control population (p < 0.0001), High prevalence of DL a nd/or HU associated with DM was observed among patients with DISH (p < 0.0001), Patients with uncomplicated diabetes (or DL or HU) were almo st equally distributed between the 2 groups, with no significant diffe rences (p > 0.1). Combined metabolic features of DM+DL, DM+HU, or DM+D L+HU were shown to be the main risk factor for DISH (K = 14), They may constitute a metabolic syndrome with high diagnostic specificity (u = 1.0) and nosologic sensitivity (g = 1.0), despite their lowest preval ence (0.07), Dyslipidemia occurred with the highest prevalence (p = 0. 36), the highest positive predictive value (v = 0.44) and, together wi th HU and diabetes, the highest nosologic specificity (f = 0.55 in bot h cases). Conclusion, We found metabolic disturbances confined to the group with DISH. Followup studies of the number of bridging ossificati ons in identically aged patients or bridging ossifications/year/patien t could be a useful tool to determine their effect on the extent and p rogression rates of DISH.