G. Vezyroglou et al., A METABOLIC SYNDROME IN DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS, A CONTROLLED-STUDY, Journal of rheumatology, 23(4), 1996, pp. 672-676
Objective. In addition to diabetes mellitus (DM), high incidence of co
mmon metabolic conditions such as dyslipidemia (DL) and hyperuricemia
(HU) has been found in patients with diffuse idiopathic skeletal hyper
ostosis (DISH). Our objective was to confirm such observations compari
ng data from patients with DISH and appropriate controls. Methods, One
hundred randomly identified inpatients with DISH were compared with 1
00 DISH-free inpatients with various rheumatic disorders matched for a
ge, sex, body mass index, and excess body weight, The prevalence of me
tabolic disturbances was compared in the 2 groups, Data was analyzed s
tatistically by chi-squared test and 4-fold table analysis. Results, I
n our DISH population, metabolic abnormalities were found in 70%, vers
us 45% in the control population (p < 0.0001), High prevalence of DL a
nd/or HU associated with DM was observed among patients with DISH (p <
0.0001), Patients with uncomplicated diabetes (or DL or HU) were almo
st equally distributed between the 2 groups, with no significant diffe
rences (p > 0.1). Combined metabolic features of DM+DL, DM+HU, or DM+D
L+HU were shown to be the main risk factor for DISH (K = 14), They may
constitute a metabolic syndrome with high diagnostic specificity (u =
1.0) and nosologic sensitivity (g = 1.0), despite their lowest preval
ence (0.07), Dyslipidemia occurred with the highest prevalence (p = 0.
36), the highest positive predictive value (v = 0.44) and, together wi
th HU and diabetes, the highest nosologic specificity (f = 0.55 in bot
h cases). Conclusion, We found metabolic disturbances confined to the
group with DISH. Followup studies of the number of bridging ossificati
ons in identically aged patients or bridging ossifications/year/patien
t could be a useful tool to determine their effect on the extent and p
rogression rates of DISH.