A POLYSACCHARIDE-PEPTIDE COMPLEX FROM CULTURED MYCELIA OF THE MUSHROOM TRICHOLOMA-MONGOLICUM WITH IMMUNOENHANCING AND ANTITUMOR ACTIVITIES

A polysaccharide-peptide complex with immunoenhancing and antitumor ac tivities was obtained from the mycelial culture of Tricholoma mongolic um, an edible mushroom found in Northern China. The polysaccharide-pep tide complex had a molecular mass of 15.5 kDa, as estimated by gel fil tration, and a carbohydrate-protein ratio of about 8:1 and was not ads orbed on DEAE - Sepharose CL-6B. It possessed the activities of activa ting macrophages, stimulating macrophage antigen-presenting activity, which in turn enhanced proliferation of T-cells, and inhibiting the gr owth of sarcoma 180 cells that had been implanted in mice.