N. Shimura et al., DETERMINATION OF ESTROGEN 3-SULFATES IN BIOLOGICAL-FLUIDS OF MAMMARY TUMOR-BEARING RATS BY RADIOIMMUNOASSAY, Nuclear medicine and biology, 20(4), 1993, pp. 493-501
Determination of estradiol 3-sulfate (E, 3-S) and estriol 3-sulfate (E
3 3-S) in plasma, urine or tumor tissues of mammary tumor-bearing rats
were performed using the superior radioimmunoassay (RIA) system. The
plasma level of E2 3-S after tumorigenesis was found to be about one-t
hird of the normal level. As to E3 3-S, the levels in urine were signi
ficantly high both before and after tumorigenesis. Before that, the av
erage level was about 1.5 times, and after that, about 2.5 times as hi
gh as the normal level. In tumor tissues, an extremely high level of E
3 3-S (399.6 +/- 113.9 pg/g tissue) was determined.