3-THIO-5-(N-ARYL-N'-ARYLGUANYL)-1,2,4-DITHIAZOLES AS POTENTIAL ANTI-CONVULSANT AND ANALGESIC AGENTS

The synthesis and biological activities of a number of substituted 3-t hio-5-(N-aryl-N'-arylguanyl)-1,2,4-dithiazoles are reported. The aroma tic substitutents m-CH3 3, p-CH3 4 and p-bromo 11 produced compounds w ith potent anti-convulsant properties in rats and compared favorably w ith the standard anti-convulsant drugs phenytoin and phenobarbitone-so dium in a number of test situations. In the analgesic test, most of th e compounds exhibited analgesic activity with particular reference to p-CH3 4 substitution being most potent in the series.