EXOCRINE PANCREATIC RESPONSE TO INTRADUODENAL FATTY-ACIDS AND FATS INRABBITS

1. The exocrine pancreatic secretion in rabbits after intraduodenal pe rfusion of, respectively, a short-chain fatty acid (propionate), a lon g-chain fatty acid (oleate) and a neutral fat (intralipid) has been st udied. 2. Only the neutral fat and the long-chain fatty acid stimulate d the hydroelectrolyte fraction of exocrine pancreatic secretion in a dose-related fashion, but this response was not mediated by secretin r elease. 3. Acinar secretion was more effectively stimulated after prop ionate perfusion than by oleate and this was governed by different mec hanisms. 4. Neutral fat, without predigestion, stimulated the pancreat ic enzyme secretion in the rabbit.