This prospective study was undertaken to determine the incidence and f
actors predisposing to vaso-vagal reactions during venous cannulation
in an ambulatory surgery population. In 141 ambulatory surgery patient
s, signs and symptoms of a reaction together with mean arterial pressu
re and heart rate were recorded at 1-min intervals during and for 6 mi
n after venous cannulation. Overall, 10.6% of patients were symptomati
c (95% confidence interval [CI] 6%-17%). The incidence was 16.6% (95%
CI 8.4%-24.9%) in patients less-than-or-equal-to 40 yr and 33.3% (95%
CI 6.7%-60.0%) with a prior fainting history. Young age, duration or n
umber of attempts at venous cannulation, and fainting history were ind
ependently associated with increased risk of a reaction (P < 0.03-0.00
4 by multiple repression analysis). Minimum mean arterial pressure was
less in symptomatic patients than in those who were asymptomatic (58
mm Hg +/- 11.3 SD versus 82 mm Hg +/- 14.3 SD, P < 0.0001). We conclud
e that reactions occur commonly, particularly in the young or in patie
nts with a history of fainting. Reactions are typically associated wit
h significant hypotension that may require treatment.