DEPLETION OF MAC1-POSITIVE MACROPHAGES PROTECTS DBA 2 MICE FROM ENCEPHALOMYOCARDITIS VIRUS-INDUCED MYOCARDITIS AND DIABETES/

Authors
HIRASAWA K TSUTSUI S TAKEDA M MIZUTANI M ITAGAKI S DOI K
Citation
K. Hirasawa et al., DEPLETION OF MAC1-POSITIVE MACROPHAGES PROTECTS DBA 2 MICE FROM ENCEPHALOMYOCARDITIS VIRUS-INDUCED MYOCARDITIS AND DIABETES/, Journal of General Virology, 77, 1996, pp. 737-741
Citations number
17
Categorie Soggetti
Virology,"Biothechnology & Applied Migrobiology
Journal title
Journal of General Virology → ACNP
ISSN journal
00221317
Volume
77
Year of publication
1996
Part
4
Pages
737 - 741
Database
ISI
SICI code
0022-1317(1996)77:<737:DOMMPD>2.0.ZU;2-P
Abstract
DBA/2 mice treated with anti-Mac1 monoclonal anti-body (Mab) failed to develop encephalomyocarditis virus (EMCV)-induced diabetes and myocar ditis. Virus concentrations and the number of viral RNA-positive cells in the pancreas and heart were significantly reduced in mice treated with anti-Mac1 Mab. Mac1-positive macrophages seem to be involved in E MCV-induced disease and to affect the replication of EMCV in target or gans.