SYNTHESIS, SPECTRAL, THERMAL, AND BIOLOGICAL STUDIES OF ADDUCTS OF ORGANOTIN(IV) HALIDES WITH SCHIFF-BASES DERIVED FROM 2-AMINO-5-(O-METHOXYPHENYL)-1,3,4-THIADIAZOLE

Some new organotin(IV) complexes of the general formula, R(n)SnCl(4-n) . L [where n = 3, R = CH3 or C6H5; n = 2, R = C6H5; L = Schiff bases d erived from the condensation of 2-amino-5-(o-methoxyphenyl)-1,3,4-thia diazole with salicyl aldehyde (L-l), 2-hydroxy-1-naphthaldehyde (L-2), 2'-hydroxyacetophenone (L-3), benzyl methyl ketone (L-4), acetylaceto ne (L-5), and 2-furancarbaldehyde (L-6)] have been synthesized and cha racterized by elemental analyses, molar conductances, electronic, infr ared, far-infrared, H-1 and (119)SnNMR and Mossbauer spectral studies. Thermal studies of three complexes, viz., Ph(3)SnCl(L-2), Me(3)SnCl(L -4), and Ph(3)SnCl(L-5) have been carried out in the temperature range 25-1000 degrees C using TG, DTG, and DTA techniques. All these comple xes decompose gradually with the formation of SnO2 as an end product. In vitro antimicrobial activity of the ligands and their complexes has also been determined against Streptococcus faecalis, Klebsiella pneum oniae, Escherichia coil, Pseudomonas aeruginosa, Staphylococcus aureus Penicillin resistance (2500 units), Candida albicans, Cryptococcus ne oformans, Sporotrichum schenckii, Trichophyton mentagrophytes, and Asp ergillus fumigatus.