EVALUATION OF THE EFFECTIVENESS OF VAGINAL MISOPROSTOL TO INDUCE FIRST TRIMESTER ABORTION

Two doses, 200 and 400 mu g, of misoprostol, administered vaginally ev ery 12 hours, up to four times, were tested in 101 and 133 healthy wom en, respectively, for interruption of pregnancies with 35 through 77 d ays of amenorrhea. The proportion of women who aborted increased with longer duration of treatment and was significantly higher with 400 tha n with 200 mu g (66 versus 46 percent at 48 hours). Significance was m aintained after controlling by age, body weight, parity, previous abor tion and gestational age. Abortions were classified as incomplete or c omplete, according to the presence or not of embryonic tissue in the u terine cavity, diagnosed by Vaginal sonography. Vacuum aspiration was carried out in all cases not classified as complete abortion 48 hours after the initiation of treatment, or earlier in case of persistent bl eeding or woman's request. The possibility of increasing effectiveness by using higher dose, shorter intervals or longer duration of treatme nt is discussed.