ANTIFERTILITY EFFECTS OF (-S-2-AMINO-6-IODOACETAMIDOHEXANOIC ACID (2-AIHA) IN FEMALE RATS())

(+)-S-2-amino-6-iodoacetamidohexanoic acid (AIHA), an irreversible inh ibitor of the ornithindecarboxylase and extrahepatic arginase enzymati c activities with antineoplasic properties, was evaluated for antifert ility activity in pregnant rats by oral administration at different pe riods of gestation. Our results showed that doses of 10 and 20 mg/kg o f AIHA orally administered produced a contraceptive effect when it was administered from days 2 to 5, and 8 to 12 of gestation, respectively . The gestation time was slightly shortened when AIHA was applied from day 15 until labor. No sign of external malformations in fetuses was observed. On the other hand, AIHA did not affect the total length of o estrous cycle at the same dosage level used to interrupt pregnancy. In ovariectomized immature rats, neither changes in uterine weight, prem ature vaginal opening, or cornified cells were found. However, AIHA en hanced the estradiol-induced increase in uterine weights when both wer e concomitantly administered.