USE OF THE ABIOTIC PROTON BALANCE FOR DETERMINING LINEAR RELATIONS AMONG NET CONVERSION RATES OF PRIMARY METABOLITES IN FERMENTATION PROCESSES

Linear relations among net conversion rates of primary metabolites in fermentation processes can be determined by using the macroscopic or p athway balancing methods. it is shown that the process observability c an be improved by incorporating both the abiotic proton balance and th e pH control reagent addition rate measurement into the balancing meth ods. (C) 1996 John Wiley & Sons, Inc.