THE IMMUNOMODULATORY AND ANTITUMOR ACTIVITIES OF LECTINS FROM THE MUSHROOM TRICHOLOMA-MONGOLICUM

Citation
Hx. Wang et al., THE IMMUNOMODULATORY AND ANTITUMOR ACTIVITIES OF LECTINS FROM THE MUSHROOM TRICHOLOMA-MONGOLICUM, Immunopharmacology, 31(2-3), 1996, pp. 205-211
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
ISSN journal
01623109
Volume
31
Issue
2-3
Year of publication
1996
Pages
205 - 211
Database
ISI
SICI code
0162-3109(1996)31:2-3<205:TIAAAO>2.0.ZU;2-B
Abstract
TML-1 and TML-2 were two lectins isolated from the mushroom Tricholoma mongolicum. They did not differ appreciably in their pH stability and cationic requirement for hemagglutinating activity. They both stimula ted the production of nitrite ions and activated the macrophages in mi ce. The two lectins were able to inhibit the growth of implanted sarco ma 180 cells by 68.84% and 92.39% respectively. The growth of tumor ce lls in the mouse peritoneal cavity was also inhibited by the two lecti ns with TML-2 expressing a greater potency.