Hx. Wang et al., THE IMMUNOMODULATORY AND ANTITUMOR ACTIVITIES OF LECTINS FROM THE MUSHROOM TRICHOLOMA-MONGOLICUM, Immunopharmacology, 31(2-3), 1996, pp. 205-211
TML-1 and TML-2 were two lectins isolated from the mushroom Tricholoma
mongolicum. They did not differ appreciably in their pH stability and
cationic requirement for hemagglutinating activity. They both stimula
ted the production of nitrite ions and activated the macrophages in mi
ce. The two lectins were able to inhibit the growth of implanted sarco
ma 180 cells by 68.84% and 92.39% respectively. The growth of tumor ce
lls in the mouse peritoneal cavity was also inhibited by the two lecti
ns with TML-2 expressing a greater potency.