A HUMAN PROTECTIVE PROTEIN GENE PARTIALLY OVERLAPS THE GENE ENCODING PHOSPHOLIPID TRANSFER PROTEIN ON THE COMPLEMENTARY STRAND OF DNA

The entire human protective protein gene has been cloned, and structur al analysis revealed that the gene spans 7.5kb and comprises 15 exons. Furthermore, it partially overlaps on the opposite strand with the ge ne encoding phospholipid transfer protein. This region of DNA on chrom osome 20 appears to encode two distinct mRNAs expressing defined funct ional products, and the mRNAs overlap by 58 nucleotides at their 3'-un translated ends. (C) 1996 Academic Press, Inc.