CUTTING APART V(D)J RECOMBINATION

Authors
OETTINGER MA
Citation
Ma. Oettinger, CUTTING APART V(D)J RECOMBINATION, Current opinion in genetics & development, 6(2), 1996, pp. 141-145
Citations number
43
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
6
Issue
2
Year of publication
1996
Pages
141 - 145
Database
ISI
SICI code
0959-437X(1996)6:2<141:CAVR>2.0.ZU;2-R
Abstract
The past year has seen major advances in our understanding of the reco mbination mechanism by which antibody and T cell receptor genes are as sembled during lymphoid development. The initial cleavage events can b e carried out in vitro by purified RAG1 and RAG2 protein. In addition, a number of genes involved in later steps of the reaction have been c loned, opening the way for an in-depth biochemical analysis of this cr itical developmental process.