TRANSIENT RENAL IMPAIRMENT IN ACUTE INTRACEREBRAL HEMORRHAGE

Transient impairment of renal function was found in 30 of 78 patients with acute intracerebral haemorrhage (ICH). Patients with a history of renal disease, dehydration, nephrotoxic drugs or septicaemia were exc luded. In the Ist week, the mean serum creatinine level was 3.4 (range 1.7-7.7) mg/dl, which returned to normal in 2-4 weeks, Employing mult ivariate stepdown logistic regression analysis, Glasgow Coma Scale sco re and pulse pressure were found to be significantly related to renal impairment manifesting with a raised serum creatinine level, whereas p upillary asymmetry was of borderline significance. An acute rise in in tracranial pressure following ICH may result in sympathetic overactivi ty, which may account for the renal impairment observed in our patient s.