The forced vital capacity (FVC) maneuver is the most common lung funct
ion test. One of its major prerequisites is that it be performed with
sufficient effort to achieve the maximal flows that are due to expirat
ory flow limitation. To verify this, in nine normal subjects, short (0
.25-s) pulses of negative pressure (-5 to -20 cmH(2)O) were applied at
the mouth at different times (0.25-1 s) after the onset of 1) FVC man
euvers and 2) vital capacity expirations with submaximal expiratory ef
forts (SVC). All subjects were experienced in FVC maneuvers. With FVC,
the expiratory flow did not change with application and removal of ne
gative-pressure pulses, apart from brief flow transients, mainly refle
cting displacement of air from the compliant oral and neck structures.
With SVC, flow increased throughout the application of the negative-p
ressure pulses. Thus application of pulses of negative pressure provid
es a simple method for on-line recognition of whether an FVC maneuver
is performed with sufficient effort to achieve flow limitation.