FLOW CYTOMETRIC DNA ANALYSIS OF ABNORMAL ENDOMETRIUM

Samples of abnormal endometrium, which were composed of 5 cases of aty pical hyperplasia (ATH), 12 cases of well differentiated adenocarcinom a (G1), 17 cases of moderately differentiated adenocarcinoma (G2), 11 cases of poorly differentiated adenocarcinoma (G3) and 2 cases of sero us papillary adenocarcinoma (SPA), were analyzed by flow cytometry. Wi th respect to the ploidy level, all cases of both ATH and G1 showed di ploidy, and the proliferative index (PI) was 14.32 and 16.33, respecti vely. In contrast, 3 of G2 cases, 3 of G3 cases and all of SPA cases s howed aneuploid patterns, and the PI was 21.06, 27.91 and 31.52, respe ctively. There were statistical differences between the former group a nd the latter group as to both the ploidy and the PI. It was found tha t ATH and G1 had similar biological behavior.