ANALYTICAL PROPERTIES OF 2-DISUBSTITUTED AND 10-DISUBSTITUTED PHENOTHIAZINE-DERIVATIVES

Phenothiazine derivatives substituted in the 2 and 10 positions belong to a big group of tricyclic aromatic compounds. They are in extensive use in psychiatry as tranquilizers and neuroleptics. Due to their cha racteristic structure they exhibit many valuable analytical properties . They are easily oxidized in an acidic medium while generating color products. They also react with some thiocyanate and halide complexes o f metals as well as some organic compounds, and form well-defined ion- association complexes. The properties mentioned above are the basis fo r utilizing the phenothiazine derivatives as reagents for chemical ana lysis. The physical and chemical properties of 2,10-disubstituted phen othiazine derivatives are described in the presented paper in detail. The paper is divided into seven parts. The first chapter presents the physical properties of the phenothiazine derivatives, such as their ph ysical state, thermal stability and solubility. The next part of the p aper is devoted to the spectral properties of 2,10-disubstituted pheno thiazine derivatives. The influence of the type of substituents on the intensity and shape of the UV and fluorescence spectra of phenothiazi ne derivatives are discussed. Chapters 4 and 5 show the run and the me chanism of phenothiazine derivatives oxidation, their electrochemical properties and the analytical aspects of the described processes. Chap ter 6 of the present paper is devoted to the complexing abilities of t he phenothiazine derivatives. The paper is based on a review of the ch emical literature up to 1995. A short specification of the analytical methods utilizing the physical and chemical properties of the phenothi azine derivatives is also included.