COMBINED GAS-CHROMATOGRAPHY INFRARED-SPECTROSCOPY FOR THE DETERMINATION OF PROPANEDIOL IN ACYCLOVIR CREAM

Authors
GILBERT AS MOSS CJ FRANCIS PL ASHTON MJ ASHTON DS
Citation
As. Gilbert et al., COMBINED GAS-CHROMATOGRAPHY INFRARED-SPECTROSCOPY FOR THE DETERMINATION OF PROPANEDIOL IN ACYCLOVIR CREAM, Chromatographia, 42(5-6), 1996, pp. 305-308
Citations number
5
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Chromatographia → ACNP
ISSN journal
00095893
Volume
42
Issue
5-6
Year of publication
1996
Pages
305 - 308
Database
ISI
SICI code
0009-5893(1996)42:5-6<305:CGIFTD>2.0.ZU;2-5
Abstract
A simple procedure is described for the determination of the 1,2-propa nediol (propylene glycol) content of cream formulations containing the antiviral drug Acyclovir. Analysis of a solvent extract by gas chroma tography coupled to an infra-red spectrometer enables the target analy te to be positively identified and an estimate of its concentration to be made. This application utilises the newer Tracer cryogenic deposit ion interface for gas chromatography and infra-red spectroscopy. This offers an alternative and complementary analytical strategy to gas chr omatography coupled to mass spectrometry.