Objectives: To estimate the extent of the HIV/AIDS epidemic among Ital
ian women and to assess its impact on mortality. Further, to assess th
e incidence of AIDS and the main characteristics of women affected by
AIDS, with particular attention to those aged 25-34 years, and to iden
tify differences in these characteristics compared with men infected w
ith AIDS. Methods: Incidence data were derived from the Italian Nation
al Register of AIDS Cases (RAIDS). The most recent complete data refer
to cases diagnosed to the end of 1994. Mortality data were collected
from the Italian mortality database, which is held by the Italian Nati
onal Census Bureau (ISTAT) and processed by the Laboratory of Epidemio
logy and Biostatistics at the National Institute of Health of Italy (I
stituto Superiore di Sanita; ISS). The most recent mortality data refe
r to 1992, but projections were made to obtain mortality data up to 19
94. All the rates were standardized by age and sex. Results: A total o
f 26 957 cases of AIDS, 21 441 men (79.5%) and 5516 women (20.5%), dia
gnosed before the end of 1994 were reported to RAIDS. The majority of
cases and deaths occurred in individuals aged 25-34 years. The inciden
ce of AIDS among women increased from 2.1 per 100 000 in 1987 to 17.2
per 100 000 in 1994. The sex ratio (men:women) fell from 5.2 in 1987 t
o 2.9 in 1994. In 1992, AIDS was the second most common cause of death
(slightly behind cancer and ahead of traffic accidents) in Italy but
was the most common cause in three regions of northern Italy (Liguria,
Lombardia and Emilia). Conclusions: Although the AIDS epidemic in the
past has predominantly affected young men, AIDS is now rapidly becomi
ng a major health problem for young women in Italy. Moreover, as these
women are at reproductive age, this may have important consequences i
n terms of increased morbidity and mortality among children.