BENZYLOXYCARBONYL-VAL-ALA-ASP (OME) FLUOROMETHYLKETONE (Z-VAD.FMK) INHIBITS APOPTOSIS BY BLOCKING THE PROCESSING OF CPP32

Authors
SLEE EA ZHU HJ CHOW SC MACFARLANE M NICHOLSON DW COHEN GM
Citation
Ea. Slee et al., BENZYLOXYCARBONYL-VAL-ALA-ASP (OME) FLUOROMETHYLKETONE (Z-VAD.FMK) INHIBITS APOPTOSIS BY BLOCKING THE PROCESSING OF CPP32, Biochemical journal, 315, 1996, pp. 21-24
Citations number
32
Categorie Soggetti
Biology
Journal title
Biochemical journal → ACNP
ISSN journal
02646021
Volume
315
Year of publication
1996
Part
1
Pages
21 - 24
Database
ISI
SICI code
0264-6021(1996)315:<21:B(F(I>2.0.ZU;2-J
Abstract
Interleukin-1 beta converting enzyme (ICE)-like proteases, which are s ynthesized as inactive precursors, play a key role in the induction of apoptosis. We now demonstrate that benzyloxycarbonyl-Val-Ala-Asp (OMe ) fluoromethylketone (Z-VAD.FMK), an ICE-like protease inhibitor, inhi bits apoptosis by preventing the processing of CPP32 to its active for m. These results suggest that novel inhibitors of apoptosis can be dev eloped which prevent processing of proforms of ICE-like proteases.