TRANSDERMAL ESTROGEN REPLACEMENT THERAPY IN NORMAL PERIMENOPAUSAL WOMEN - EFFECTS ON PITUITARY-OVARIAN FUNCTION

The effects of 6 months of hormone replacement therapy by transdermal estradiol patches (0.05 mg/day for 21 days) and oral progestogens (10 mg/day for 10 days) on hypothalamic-pituitary-ovarian function was eva luated in 32 perimenopausal women, aged 42-47 years, with irregular an ovulatory cycles and menopausal symptoms. Hormone levels evaluated on the 8th and 24th day of the cycle preceding therapy showed follicle-st imulating hormone (FSH) levels above 15 mIU/ml, estradiol less than 45 pg/ml and progesterone less than 800 pg/ml. During therapy, there was an improvement in menopausal symptoms, a decrease in luteinizing horm one (LH) and FSH levels, an increase in estradiol levels and the trans dermal patches were well tolerated. Ar the end of therapy, 19 women co ntinued to have regular ovulatory cycles with progesterone levels simi lar to those in luteal phase. FSH and LH concentrations were significa ntly lower than before therapy. This study shows that hormone replacem ent therapy not only improves menopausal symptoms but may also restore the hypothalamic-pituitary-ovarian function.