SURFACTANT - CURRENT AND POTENTIAL THERAPEUTIC APPLICATION IN INFANTSAND ADULTS

Citation
J. Lewis et Raw. Veldhuizen, SURFACTANT - CURRENT AND POTENTIAL THERAPEUTIC APPLICATION IN INFANTSAND ADULTS, Journal of aerosol medicine, 9(1), 1996, pp. 143-154
Citations number
43
Categorie Soggetti
Public, Environmental & Occupation Heath
Journal title
ISSN journal
08942684
Volume
9
Issue
1
Year of publication
1996
Pages
143 - 154
Database
ISI
SICI code
0894-2684(1996)9:1<143:S-CAPT>2.0.ZU;2-Y
Abstract
Exogenous surfactant administration is currently being evaluated for t he Acute Respiratory Distress Syndrome (ARDS). Although surfactant sup plementation is now a routine therapy for babies born with neonatal RD S, this treatment modality for adults does not appear to result in a p redictable improvement in lung function as is noted in neonates. This article will review the basic abnormalities of the surfactant system i n patients with ARDS and contrast them with the primary surfactant def icient state of nRDS. Various factors that have been shown to influenc e an individual's response to exogenous surfactant will the be outline d. Finally, potential treatment approaces for patiens with ARDS utiliz ing exogenous surfactant mill be proposed.