PHARMACOKINETICS, PLASMA-PROTEIN BINDING AND DOSAGE REGIMEN OF SULFADIMETHOXINE IN BUFFALO CALVES

Authors
SRIVASTAVA AK CHAUDHARY RK BAL MS
Citation
Ak. Srivastava et al., PHARMACOKINETICS, PLASMA-PROTEIN BINDING AND DOSAGE REGIMEN OF SULFADIMETHOXINE IN BUFFALO CALVES, Indian Journal of Animal Sciences, 66(3), 1996, pp. 215-218
Citations number
14
Categorie Soggetti
Veterinary Sciences","Agriculture Dairy & AnumalScience
Journal title
Indian Journal of Animal Sciences → ACNP
ISSN journal
03678318
Volume
66
Issue
3
Year of publication
1996
Pages
215 - 218
Database
ISI
SICI code
0367-8318(1996)66:3<215:PPBADR>2.0.ZU;2-Y
Abstract
The pharmacokinetics, protein binding and dosage regimen of sulphadime thoxine were investigated in buffalo calves following a single intrave nous dose of 100 mg/kg. The distribution of half-life. (t1/2 alpha), e limination half-life (t(1/2) beta) and Vd were 0.13+/-0.02 hr, 32.4+/- 2.91 hr and 2.28+/-0.33 L. kg(-1) respectively. Total body clearance w hich represents the sum of all clearance processes and tissue/plasma ( T/P) ratio were calculated to be 52.3+/-10.4 ml. kg(-1). hr(1) and 6.0 8+/-0.01 respectively. Sulphadimethoxine binding with plasma proteins was to the extent of 74.5+/-1.53%.