PERIOPERATIVE USE OF AMPICILLIN-SULBACTAM, CEFOXITIN AND PIPERACILLINMETRONIDAZOLE IN ELECTIVE COLON AND RECTUM SURGERY - A PROSPECTIVE AND RANDOMIZED QUALITY-CONTROL STUDY IN 422 PATIENTS (REPRINTED FROM CHIRURG, VOL 64, PG 649-652, 1993)
J. Menzel et al., PERIOPERATIVE USE OF AMPICILLIN-SULBACTAM, CEFOXITIN AND PIPERACILLINMETRONIDAZOLE IN ELECTIVE COLON AND RECTUM SURGERY - A PROSPECTIVE AND RANDOMIZED QUALITY-CONTROL STUDY IN 422 PATIENTS (REPRINTED FROM CHIRURG, VOL 64, PG 649-652, 1993), International journal of antimicrobial agents, 6, 1996, pp. 79-82
As previous work has shown, antibiotic prophylaxis is highly effective
in lowering wound infection rates in colorectal surgery. In order to
establish quality control, the authors investigated the effectiveness
of three different prophylactic antibiotic regimes in 422 patients in
a prospective and randomized trial. There were no significant differen
ces between the three groups with regard to age, type of operation and
risk factors like adipositas and diabetes. The wound infection rate a
ccording to the Centers for Disease Control criteria ranged from 7.0%
to 9.5%. No significant difference was found between the three antibio
tic regimes. It can be concluded, therefore, that under the conditions
used in this study each of the three different types of antibiotics i
s of equal value, hence, the cheapest one can be used.