L. Greenhouse et Ck. Lardinois, ALCOHOL-ASSOCIATED DIABETES-MELLITUS - A REVIEW OF THE IMPACT OF ALCOHOL-CONSUMPTION ON CARBOHYDRATE-METABOLISM, Archives of family medicine, 5(4), 1996, pp. 229-233
Most cases of diabetes mellitus result from decrease insulin secretion
(type I, insulin-dependent) or altered insulin action (type II, insul
in-independent). Another category, namely, ''other'' diabetes mellitus
-associated conditions, is usually mentioned to distinguish this type
of diabetes from the other two categories; this category includes drug
s, genetic and endocrine syndromes, and pancreatic disorders. The most
common pancreatic disease that causes diabetes mellitus is chronic pa
ncreatitis that results from alcohol abuse. The clinical observation o
f patients at our institution with long histories of heavy alcohol int
ake and diabetes mellitus prompted us to review the impact of alcohol
on carbohydrate metabolism. In many of these patients, it was notable
that they were not obese and they had no immediate family members with
diabetes mellitus, raising the possibility that alcohol-associated di
abetes mellitus may be a distinct subset of non-insulin-dependent diab
etes mellitus that is distinct from type II diabetes mellitus.